Reviewed by Peptide Treatments Medical Advisory Board (Medical Advisory Board)

Melanotan II: Contraindications & Drug Interactions

Safety information for Melanotan II including known contraindications, drug interactions, and important precautions.

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Contraindications

  • History of melanoma or dysplastic nevi
  • Cardiovascular disease
  • Pregnancy and breastfeeding

Drug Interactions (2 interactions)

Important: This table summarizes known and theoretical interactions. Always consult a healthcare provider before combining Melanotan II with any medication.
Drug Classification Mechanism
PDE5 inhibitors (sildenafil, tadalafil) Documented Additive vasodilation and erectile effects — increased risk of hypotension
Antihypertensives Theoretical Melanotan II can cause transient blood pressure changes

Use our interactive Drug Interaction Checker for real-time lookup.